The earliest inhabitants of the Karachi region are believed to have been hunter-gatherers, with ancient flint tools discovered at several sites.A sea port called Barbarikon by the Greeks was situated in Karachi.
The name Karachee was used for the first time in a Dutch document from 1742, in which a merchant ship de Ridderkerk is shipwrecked near the original settlement.
By 1899, Karachi had become the largest wheat-exporting port in the East.
British development projects in Karachi resulted in an influx of economic migrants from several ethnicities and religions, including Anglo-British, Parsis, Marathis, and Goan Christians, among others.
Under his rule, fortifications in the region acted as a bulwark against Portuguese incursions into Sindh.
The Ottoman admiral, Seydi Ali Reis, mentioned Debal and Manora Island in his book Mir'ât ül Memâlik in 1554.